Forschung

We investigate molecular structure, dynamics and interactions giving rise to exciting phenomena at the intersection of chemistry, physics and biology. To this end we develop novel spectroscopic techniques that combine structure sensitivity with high time resolution. Many experiments are based on transient multidimensional infrared spectroscopy and the use of non-canonical amino acids as tools for studying protein biophysics.

Achilleas Frangakis

To visualize and understand the orchestration of macromolecular machines we use an arsenal of biophysical technologies such as advanced microscopy techniques, high-resolution structural methods, molecular modeling, but primarily cryo-electron tomography combined with machine learning techniques. These technologies we use to understand adhesion mechanisms in both eukaryotes and bacteria. To enable adhesion the cell develop intricate structures with complex architectures.

Gerhard Hummer

Our goal is to develop detailed and quantitative descriptions of key biomolecular processes, including energy conversion, molecular transport, signal transduction, and enzymatic catalysis. The growing understanding of the function of living organisms at the molecular level increasingly drives advances in modern medicine. Moreover, revealing the physical and chemical mechanisms exploited in biological systems guides the development of new technologies. In our research we develop, implement, and use a broad range of computational and theoretical methods that allow us to explore the structure, stability, dynamics, and molecular functions of biomolecules and their complexes.